Tree of Pearls

Pearls

What do you think about highimpact journals that cater to a wider audience? I used to think that such journals were for the vain and insecure; however, I’ve just had my first article accepted by Current Biology, so I must of course reconsider. I think there is a place for journals suited to the more general reader, but I do worry that the decisions for some journals — even on whether to send th...

Pearls of Algorithms

Nivolumab – Pearls of Evidence

Purpose Nivolumab is one of the most extensively studied immune checkpoint inhibitors across various tumor types. In this narrative review, the current clinical efficacy and safety data of anti-programmed death-1 (PD-1) nivolumab for nonsmall cell lung cancer (NSCLC) and renal cell cancer (RCC) are elucidated. Methods Systematic search was done on Pubmed, Medline, Embase, Web of Knowledge, an...

Capsulorhexis: Pearls and pitfalls.

A critical step in phacoemulsification (as well as extracapsular cataract extraction) is making a window in anterior capsule wall (i.e. anterior capsulotomy). Continuous Curvilinear Capsulorhexis (CCC) has become recognized as the standard method of anterior capsulectomy. Techniques employed for CCC have undergone sustained evolution. The present review evaluates elementary principles of CCC. M...

Pearls Fungal Biofilms

Biofilms are a principal form of microbial growth and are critical to development of clinical infection. They are responsible for a broad spectrum of microbial infections in the human host. Many medically important fungi produce biofilms, including Candida [1], Aspergillus [2], Cryptococcus [3], Trichosporon [4], Coccidioides [5], and Pneumocystis [6]. In this review we emphasize common feature...